Protein profile

KP13_05394

Spheroplast protein Y

Genome: KpKP13

Gene: AHE45039.1 spy Structure source: AlphaFold + ColabFold UniProt A0A0H3GRK1
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Amino acids 161
Annotations 1
Features 17
PDB binders 0
Druggability 0.676

Overview

Basic information about this protein and its source genome.

Accession
KP13_05394
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45039.1 spy
Status
annotated
Amino acids
161
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
76.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.676
Structure A0A0H3GRK1
Pocket Pocket 9
P2Rank
Structure A0A0H3GRK1
Pocket No pockets
ColabFold model
FPocket 0.348 · Pocket 3
P2Rank 0.007 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 77 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
17 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
46 141 Pfam PF07813 LTXXQ motif family protein
46 141 InterPro IPR012899 LTXXQ motif family protein
38 147 Gene3D G3DSA:1.20.120.1490 -
54 145 CDD cd09916 CpxP_like
54 145 InterPro IPR012899 LTXXQ motif family protein
2 158 PANTHER PTHR38102 PERIPLASMIC CHAPERONE SPY
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
138 161 MobiDBLite mobidb-lite consensus disorder prediction
25 161 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 151 PIRSF PIRSF034445 CpxP_Spy
1 151 InterPro IPR012899 LTXXQ motif family protein
98 118 Coils Coil Coil
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRK1
AlphaFold — — full sequence — Viewing
ColabFold KP13_05394
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.676
2 0.334
1 0.297
7 0.264