Protein profile

KP13_05395

Succinylglutamate desuccinylase

Genome: KpKP13

Gene: astE AHE45040.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLT4
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Amino acids 321
Annotations 5
Features 14
PDB binders 0
Druggability 0.678

Overview

Basic information about this protein and its source genome.

Accession
KP13_05395
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
astE AHE45040.1
Status
annotated
Amino acids
321
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0019545 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate. GO:0009017 Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate. GO:0016788 Catalysis of the hydrolysis of any ester bond. GO:0019544 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
62.848
DEG E-value
3.9399999999999997e-141
Localization
Cytoplasmic
ColabFold pLDDT
94.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.678
Structure A0A0H3GLT4
Pocket Pocket 4
P2Rank 0.953
Structure A0A0H3GLT4
Pocket Pocket 1
ColabFold model
FPocket 0.465 · Pocket 2
P2Rank 0.955 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 85 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0019545 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.
  • GO:0009017 Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate.
  • GO:0016788 Catalysis of the hydrolysis of any ester bond.
  • GO:0019544 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 319 SUPERFAMILY SSF53187 Zn-dependent exopeptidases
3 317 NCBIfam TIGR03242 succinylglutamate desuccinylase
3 317 InterPro IPR016681 Succinylglutamate desuccinylase
115 135 Coils Coil Coil
1 321 Hamap MF_00767 Succinylglutamate desuccinylase [astE].
1 321 InterPro IPR016681 Succinylglutamate desuccinylase
1 321 FunFam G3DSA:3.40.630.10:FF:000017 Succinylglutamate desuccinylase
21 310 PANTHER PTHR15162 ASPARTOACYLASE
1 321 PIRSF PIRSF017020 ASTE
46 318 Pfam PF04952 Succinylglutamate desuccinylase / Aspartoacylase family
46 318 InterPro IPR007036 Succinylglutamate desuccinylase/aspartoacylase
3 237 CDD cd03855 M14_ASTE
3 237 InterPro IPR016681 Succinylglutamate desuccinylase
1 321 Gene3D G3DSA:3.40.630.10 Zn peptidases

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLT4
AlphaFold — — full sequence — Viewing
ColabFold KP13_05395
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.678

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.72 0.927