Protein profile

KP13_05398

Arginine N-succinyltransferase

Genome: KpKP13

Gene: AHE45043.1 astA Structure source: AlphaFold + ColabFold UniProt A0A0H3GRJ6
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Amino acids 344
Annotations 2
Features 13
PDB binders 0
Druggability 0.922

Overview

Basic information about this protein and its source genome.

Accession
KP13_05398
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45043.1 astA
Status
annotated
Amino acids
344
Structure source
AlphaFold + ColabFold
GO
GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
79.651
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.922
Structure A0A0H3GRJ6
Pocket Pocket 4
P2Rank 0.967
Structure A0A0H3GRJ6
Pocket Pocket 1
ColabFold model
FPocket 0.634 · Pocket 16
P2Rank 0.957 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 101 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine.
  • GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 337 PANTHER PTHR30420 N-SUCCINYLARGININE DIHYDROLASE
3 337 NCBIfam TIGR03243 arginine and ornithine succinyltransferase subunits
3 337 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
273 337 Gene3D G3DSA:2.40.40.20 -
1 337 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 337 InterPro IPR016181 Acyl-CoA N-acyltransferase
1 343 Hamap MF_01171 Arginine N-succinyltransferase [astA].
1 343 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
3 337 NCBIfam TIGR03244 arginine N-succinyltransferase
3 337 InterPro IPR017650 Arginine N-succinyltransferase
1 183 Gene3D G3DSA:3.40.630.30 -
1 335 Pfam PF04958 Arginine N-succinyltransferase beta subunit
1 335 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRJ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05398
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.922

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.62 0.908
2 3.32 0.117
3 2.49 0.069
4 1.62 0.026
5 1.39 0.017