Protein profile

KP13_05404

carboxymuconolactone decarboxylase family protein

Genome: KpKP13

Gene: AHE45048.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRX0
Export view
Amino acids 186
Annotations 1
Features 10
PDB binders 0
Druggability 0.739

Overview

Basic information about this protein and its source genome.

Accession
KP13_05404
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45048.1
Status
annotated
Amino acids
186
Structure source
AlphaFold + ColabFold
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
79.121
DEG E-value
4.71e-108
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.739
Structure A0A0H3GRX0
Pocket Pocket 7
P2Rank 0.951
Structure A0A0H3GRX0
Pocket Pocket 1
ColabFold model
FPocket 0.39 · Pocket 2
P2Rank 0.953 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 57 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
22 175 PANTHER PTHR34846 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)
1 32 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 186 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
51 122 Pfam PF02627 Carboxymuconolactone decarboxylase family
51 122 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
33 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
38 172 Gene3D G3DSA:1.20.1290.10 -
38 172 InterPro IPR029032 AhpD-like
2 173 SUPERFAMILY SSF69118 AhpD-like
2 173 InterPro IPR029032 AhpD-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRX0
AlphaFold — — full sequence — Viewing
ColabFold KP13_05404
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.739

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.77 0.922