Protein profile

KP13_05406

Inner membrane ABC transporter permease protein

Genome: KpKP13

Gene: AHE45050.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVW7
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Amino acids 511
Annotations 3
Features 54
PDB binders 0
Druggability 0.746

Overview

Basic information about this protein and its source genome.

Accession
KP13_05406
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45050.1
Status
annotated
Amino acids
511
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.746
Structure A0A0H3GVW7
Pocket Pocket 1
P2Rank 0.9
Structure A0A0H3GVW7
Pocket Pocket 1
ColabFold model
FPocket 0.972 · Pocket 1
P2Rank 0.974 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 46 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

54 records
Show feature table
Start End DB Term Name
7 258 Gene3D G3DSA:1.10.3720.10 -
7 258 InterPro IPR035906 MetI-like superfamily
2 498 PANTHER PTHR30183 MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB
303 313 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
30 52 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
112 130 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
420 442 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
482 504 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
339 375 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
202 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
314 338 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
131 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
177 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
347 367 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
420 445 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
400 419 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
53 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
261 279 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
280 302 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
157 176 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
81 91 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
284 505 Gene3D G3DSA:1.10.3720.10 -
284 505 InterPro IPR035906 MetI-like superfamily
376 399 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
238 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
50 256 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
50 256 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
177 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
307 496 SUPERFAMILY SSF161098 MetI-like
307 496 InterPro IPR035906 MetI-like superfamily
207 227 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
228 238 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
281 303 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
504 511 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
446 481 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
377 399 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
348 484 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
348 484 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
10 25 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
318 340 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
371 488 CDD cd06261 TM_PBP2
371 488 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
7 255 SUPERFAMILY SSF161098 MetI-like
7 255 InterPro IPR035906 MetI-like superfamily
482 503 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
239 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVW7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05406
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
43 0.725
38 0.561
42 0.312

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.51 0.89
2 8.35 0.445
3 5.75 0.279
4 5.28 0.248
5 3.88 0.152