Protein profile

KP13_05663

Putative NAD(P)H nitroreductase

Genome: KpKP13

Gene: AHE45065.1 Structure source: Experimental + ColabFold UniProt A0A0H3GLR2
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Amino acids 198
Annotations 1
Features 11
PDB binders 0
Druggability 0.872

Overview

Basic information about this protein and its source genome.

Accession
KP13_05663
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45065.1
Status
annotated
Amino acids
198
Structure source
Experimental + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
79.781
DEG E-value
7.54e-109
Localization
Cytoplasmic
ColabFold pLDDT
93.2

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.872
Structure 7TMF
Pocket Pocket 1
P2Rank 0.244
Structure 7TMG
Pocket Pocket 1
ColabFold model
FPocket 0.474 · Pocket 11
P2Rank 0.236 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
16 197 PANTHER PTHR43821 NAD(P)H NITROREDUCTASE YDJA-RELATED
24 176 Pfam PF00881 Nitroreductase family
24 176 InterPro IPR029479 Nitroreductase
16 196 Gene3D G3DSA:3.40.109.10 NADH Oxidase
16 196 InterPro IPR000415 Nitroreductase-like
16 187 SUPERFAMILY SSF55469 FMN-dependent nitroreductase-like
16 187 InterPro IPR000415 Nitroreductase-like
13 197 PIRSF PIRSF000232 YdjA
13 197 InterPro IPR026021 Putative NAD(P)H nitroreductase YdjA-like
19 177 CDD cd02135 YdjA-like
19 177 InterPro IPR026021 Putative NAD(P)H nitroreductase YdjA-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7TMF
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
PDB 7TMG
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Loaded
ColabFold KP13_05663
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.99
2 0.99

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.12 0.235
2 5.02 0.228
3 2.67 0.079
4 2.59 0.074