Protein profile

KP13_04731

PrkA family protein

Genome: KpKP13

Gene: AHE45079.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVT5
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Amino acids 644
Annotations 4
Features 14
PDB binders 0
Druggability 0.468

Overview

Basic information about this protein and its source genome.

Accession
KP13_04731
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45079.1
Status
annotated
Amino acids
644
Structure source
AlphaFold + ColabFold
EC
2.7.11.1
GO
GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004674 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.468
Structure A0A0H3GVT5
Pocket Pocket 6
P2Rank 0.627
Structure A0A0H3GVT5
Pocket Pocket 1
ColabFold model
FPocket 0.633 · Pocket 4
P2Rank 0.718 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004674 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 644 PIRSF PIRSF000549 Ser_prot_kin
1 644 InterPro IPR016230 Serine-protein kinase, PrkA
75 157 FunFam G3DSA:3.40.50.300:FF:000609 PrkA family serine protein kinase
20 380 Pfam PF08298 PrkA AAA domain
20 380 InterPro IPR013153 PrkA AAA domain
19 380 SMART SM00763 aaa_prka2seq5
19 380 InterPro IPR013153 PrkA AAA domain
66 329 Gene3D G3DSA:3.40.50.300 -
66 329 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 643 PANTHER PTHR30267 PROTEIN KINASE PRKA
382 636 Pfam PF06798 PrkA serine protein kinase C-terminal domain
382 636 InterPro IPR010650 PrkA C-terminal domain
75 368 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
75 368 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVT5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04731
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.468
12 0.294
23 0.291
20 0.258

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.89 0.419
2 5.05 0.23
3 1.39 0.017
4 1.18 0.01