Protein profile

KP13_31956

putative HTH-type transcription regulator

Genome: KpKP13

Gene: AHE45084.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN24
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Amino acids 282
Annotations 3
Features 13
PDB binders 0
Druggability 0.802

Overview

Basic information about this protein and its source genome.

Accession
KP13_31956
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45084.1
Status
annotated
Amino acids
282
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.802
Structure A0A0H3GN24
Pocket Pocket 15
P2Rank 0.718
Structure A0A0H3GN24
Pocket Pocket 1
ColabFold model
FPocket 0.559 · Pocket 2
P2Rank 0.622 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
2 55 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
2 55 InterPro IPR000847 Transcription regulator HTH, LysR
79 270 Pfam PF03466 LysR substrate binding domain
79 270 InterPro IPR005119 LysR, substrate-binding
2 102 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
2 102 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 51 ProSiteProfiles PS50931 LysR-type HTH domain profile.
1 51 InterPro IPR000847 Transcription regulator HTH, LysR
81 276 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
80 272 Gene3D G3DSA:3.40.190.290 -
1 276 PANTHER PTHR30579 TRANSCRIPTIONAL REGULATOR
1 79 Gene3D G3DSA:1.10.10.10 -
1 79 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN24
AlphaFold — — full sequence — Viewing
ColabFold KP13_31956
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.802
10 0.368

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.37 0.608
2 4.7 0.206