Protein profile

KP13_04743

Protein umuD

Genome: KpKP13

Gene: umuD AHE45090.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN19
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Amino acids 139
Annotations 5
Features 14
PDB binders 0
Druggability 0.526

Overview

Basic information about this protein and its source genome.

Accession
KP13_04743
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
umuD AHE45090.1
Status
annotated
Amino acids
139
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0009432 An error-prone process for repairing damaged microbial DNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.526
Structure A0A0H3GN19
Pocket Pocket 2
P2Rank
Structure A0A0H3GN19
Pocket No pockets
ColabFold model
FPocket 0.156 · Pocket 2
P2Rank 0.021 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
  • GO:0009432 An error-prone process for repairing damaged microbial DNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
25 138 Gene3D G3DSA:2.10.109.10 Umud Fragment, subunit A
17 131 Pfam PF00717 Peptidase S24-like
17 131 InterPro IPR015927 Peptidase S24/S26A/S26B/S26C
10 137 PANTHER PTHR33516 LEXA REPRESSOR
13 136 SUPERFAMILY SSF51306 LexA/Signal peptidase
13 136 InterPro IPR036286 LexA/Signal peptidase-like superfamily
52 132 CDD cd06529 S24_LexA-like
52 132 InterPro IPR039418 LexA-like
63 74 PRINTS PR00726 Repressor LexA serine protease (S24) family signature
63 74 InterPro IPR006197 Peptidase S24, LexA-like
91 103 PRINTS PR00726 Repressor LexA serine protease (S24) family signature
91 103 InterPro IPR006197 Peptidase S24, LexA-like
52 62 PRINTS PR00726 Repressor LexA serine protease (S24) family signature
52 62 InterPro IPR006197 Peptidase S24, LexA-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN19
AlphaFold — — full sequence — Viewing
ColabFold KP13_04743
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.526
3 0.37
4 0.131
5 0.0