Protein profile

KP13_05605

Lipopolysaccharide 1,2-N-acetylglucosaminetransferase

Genome: KpKP13

Gene: waaU AHE45094.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLN2
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Amino acids 378
Annotations 4
Features 8
PDB binders 0
Druggability 0.541

Overview

Basic information about this protein and its source genome.

Accession
KP13_05605
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
waaU AHE45094.1
Status
annotated
Amino acids
378
Structure source
AlphaFold + ColabFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713 Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.541
Structure A0A0H3GLN2
Pocket Pocket 1
P2Rank 0.901
Structure A0A0H3GLN2
Pocket Pocket 1
ColabFold model
FPocket 0.277 · Pocket 1
P2Rank 0.903 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008713 Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.
  • GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
134 335 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase)
134 335 InterPro IPR002201 Glycosyl transferase, family 9
59 358 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
54 212 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
223 374 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
58 354 PANTHER PTHR30160 TETRAACYLDISACCHARIDE 4'-KINASE-RELATED
59 374 CDD cd03789 GT9_LPS_heptosyltransferase
59 374 InterPro IPR002201 Glycosyl transferase, family 9

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLN2
AlphaFold — — full sequence — Viewing
ColabFold KP13_05605
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.541
7 0.003
13 0.0
14 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.1 0.901
2 1.96 0.034