Protein profile

KP13_04064

Glyoxalase/bleomycin resistance protein/dioxygenase

Genome: KpKP13

Gene: AHE45136.1 Structure source: AlphaFold + ColabFold UniProt A0A483V1L6
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Amino acids 143
Annotations 1
Features 9
PDB binders 0
Druggability 0.293

Overview

Basic information about this protein and its source genome.

Accession
KP13_04064
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45136.1
Status
annotated
Amino acids
143
Structure source
AlphaFold + ColabFold
GO
GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.293
Structure A0A483V1L6
Pocket Pocket 8
P2Rank 0.02
Structure A0A483V1L6
Pocket Pocket 1
ColabFold model
FPocket 0.66 · Pocket 15
P2Rank 0.042 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
3 137 Gene3D G3DSA:3.10.180.10 -
3 137 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
10 131 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
10 131 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
10 136 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
10 136 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
12 129 CDD cd06587 VOC
9 136 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
9 136 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483V1L6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04064
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.293
9 0.29

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.19 0.01