Protein profile

KP13_04063

Antibiotic biosynthesis monooxygenase

Genome: KpKP13

Gene: AHE45137.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRC0
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Amino acids 103
Annotations 1
Features 8
PDB binders 0
Druggability 0.865

Overview

Basic information about this protein and its source genome.

Accession
KP13_04063
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45137.1
Status
annotated
Amino acids
103
Structure source
AlphaFold + ColabFold
GO
GO:0004497 Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.865
Structure A0A0H3GRC0
Pocket Pocket 1
P2Rank 0.924
Structure A0A0H3GRC0
Pocket Pocket 1
ColabFold model
FPocket 0.719 · Pocket 1
P2Rank 0.951 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 75 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004497 Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 100 PANTHER PTHR37811 BLL5343 PROTEIN
1 93 Gene3D G3DSA:3.30.70.100 -
1 98 SUPERFAMILY SSF54909 Dimeric alpha+beta barrel
1 98 InterPro IPR011008 Dimeric alpha-beta barrel
2 90 ProSiteProfiles PS51725 ABM domain profile.
2 90 InterPro IPR007138 Antibiotic biosynthesis monooxygenase domain
1 76 Pfam PF03992 Antibiotic biosynthesis monooxygenase
1 76 InterPro IPR007138 Antibiotic biosynthesis monooxygenase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRC0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04063
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.865

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.09 0.895