Protein profile

KP13_04061

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE45139.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EM73
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Amino acids 237
Annotations 7
Features 20
PDB binders 0
Druggability 0.565

Overview

Basic information about this protein and its source genome.

Accession
KP13_04061
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45139.1
Status
annotated
Amino acids
237
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0097063 Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0032791 Binding to lead (Pb) ions. GO:0046686 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
88.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.565
Structure A0A6A8EM73
Pocket Pocket 5
P2Rank 0.557
Structure A0A6A8EM73
Pocket Pocket 1
ColabFold model
FPocket 0.269 · Pocket 14
P2Rank 0.717 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 68 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0097063 Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++).
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0032791 Binding to lead (Pb) ions.
  • GO:0046686 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
  • GO:0010288 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
22 101 SMART SM00418 arsrmega2
22 101 InterPro IPR001845 HTH ArsR-type DNA-binding domain
22 95 NCBIfam NF033788 metalloregulator ArsR/SmtB family transcription factor
4 110 Gene3D G3DSA:1.10.10.10 -
4 110 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
14 101 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
14 101 InterPro IPR036390 Winged helix DNA-binding domain superfamily
8 231 PANTHER PTHR39168 TRANSCRIPTIONAL REGULATOR-RELATED
29 74 Pfam PF01022 Bacterial regulatory protein, arsR family
29 74 InterPro IPR001845 HTH ArsR-type DNA-binding domain
12 107 ProSiteProfiles PS50987 ArsR-type HTH domain profile.
12 107 InterPro IPR001845 HTH ArsR-type DNA-binding domain
24 100 CDD cd00090 HTH_ARSR
24 100 InterPro IPR011991 ArsR-like helix-turn-helix domain
57 72 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
57 72 InterPro IPR001845 HTH ArsR-type DNA-binding domain
24 39 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
24 39 InterPro IPR001845 HTH ArsR-type DNA-binding domain
72 87 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
72 87 InterPro IPR001845 HTH ArsR-type DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EM73
AlphaFold — — full sequence — Viewing
ColabFold KP13_04061
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.565
20 0.298
10 0.025
1 0.012

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.21 0.557
2 6.91 0.298