Protein profile

KP13_04055

RNA-directed DNA polymerase

Genome: KpKP13

Gene: AHE45146.1 Structure source: AlphaFold + ColabFold UniProt A0A483R7G0
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Amino acids 406
Annotations 6
Features 17
PDB binders 0
Druggability 0.506

Overview

Basic information about this protein and its source genome.

Accession
KP13_04055
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45146.1
Status
annotated
Amino acids
406
Structure source
AlphaFold + ColabFold
EC
2.7.7.49
GO
GO:0006278 A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. GO:0003964 Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0046872 Binding to a metal ion. GO:0051607 Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.506
Structure A0A483R7G0
Pocket Pocket 29
P2Rank 0.075
Structure A0A483R7G0
Pocket Pocket 1
ColabFold model
FPocket 0.332 · Pocket 6
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0006278 A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.
  • GO:0003964 Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0046872 Binding to a metal ion.
  • GO:0051607 Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
28 258 PANTHER PTHR34047 NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED
175 188 PRINTS PR00866 RNA-dependent DNA-polymerase (msDNA) signature
175 188 InterPro IPR000123 RNA-directed DNA polymerase (reverse transcriptase), msDNA
208 219 PRINTS PR00866 RNA-dependent DNA-polymerase (msDNA) signature
208 219 InterPro IPR000123 RNA-directed DNA polymerase (reverse transcriptase), msDNA
127 145 PRINTS PR00866 RNA-dependent DNA-polymerase (msDNA) signature
127 145 InterPro IPR000123 RNA-directed DNA polymerase (reverse transcriptase), msDNA
55 68 PRINTS PR00866 RNA-dependent DNA-polymerase (msDNA) signature
55 68 InterPro IPR000123 RNA-directed DNA polymerase (reverse transcriptase), msDNA
61 266 Pfam PF00078 Reverse transcriptase (RNA-dependent DNA polymerase)
61 266 InterPro IPR000477 Reverse transcriptase domain
41 267 ProSiteProfiles PS50878 Reverse transcriptase (RT) catalytic domain profile.
41 267 InterPro IPR000477 Reverse transcriptase domain
62 286 CDD cd03487 RT_Bac_retron_II
62 286 InterPro IPR000123 RNA-directed DNA polymerase (reverse transcriptase), msDNA
54 290 SUPERFAMILY SSF56672 DNA/RNA polymerases
54 290 InterPro IPR043502 DNA/RNA polymerase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483R7G0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04055
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.506

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.22 0.011