Protein profile

KP13_32234

DNA repair protein UmuC

Genome: KpKP13

Gene: AHE45147.1 Structure source: AlphaFold + ColabFold UniProt A0A486V7G9
Export view
Amino acids 248
Annotations 2
Features 8
PDB binders 0
Druggability 0.707

Overview

Basic information about this protein and its source genome.

Accession
KP13_32234
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45147.1
Status
annotated
Amino acids
248
Structure source
AlphaFold + ColabFold
GO
GO:0003684 Binding to damaged DNA. GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
81.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.707
Structure A0A486V7G9
Pocket Pocket 1
P2Rank 0.34
Structure A0A486V7G9
Pocket Pocket 1
ColabFold model
FPocket 0.239 · Pocket 18
P2Rank 0.391 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003684 Binding to damaged DNA.
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
73 172 SUPERFAMILY SSF100879 Lesion bypass DNA polymerase (Y-family), little finger domain
73 172 InterPro IPR036775 DNA polymerase, Y-family, little finger domain superfamily
70 181 Gene3D G3DSA:3.30.1490.100 -
70 181 InterPro IPR036775 DNA polymerase, Y-family, little finger domain superfamily
71 185 Pfam PF11799 impB/mucB/samB family C-terminal domain
71 185 InterPro IPR017961 DNA polymerase, Y-family, little finger domain
197 247 Pfam PF13438 Domain of unknown function (DUF4113)
197 247 InterPro IPR025188 Domain of unknown function DUF4113

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A486V7G9
AlphaFold — — full sequence — Viewing
ColabFold KP13_32234
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.707

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.29 0.058
2 1.53 0.023