Protein profile

KP13_06213

Isocitrate dehydrogenase [NADP]

Genome: KpKP13

Gene: AHE45159.1 Structure source: AlphaFold + ColabFold UniProt A0A9Q4RPB2

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Amino acids 50

Annotations 2

Features 4

PDB binders 0

Druggability 0.573

Overview

Basic information about this protein and its source genome.

Accession: KP13_06213
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE45159.1
Status: annotated
Amino acids: 50
Structure source: AlphaFold + ColabFold

GO:0006099 A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0004450 Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 100.0
DEG E-value: 5.590000000000001e-29
Localization: Cytoplasmic
ColabFold pLDDT: 97.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.573

Structure A0A9Q4RPB2

Pocket Pocket 1

P2Rank

Structure A0A9Q4RPB2

Pocket No pockets

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 182 / 4744 genomes with a hit

Normalized 0.038

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0006099 A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
GO:0004450 Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records

Show feature table

Start	End	DB	Term	Name
1	50	Gene3D	G3DSA:3.40.718.10	Isopropylmalate Dehydrogenase
1	50	PANTHER	PTHR43504	ISOCITRATE DEHYDROGENASE [NADP]
1	50	InterPro	IPR004439	Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic
1	50	SUPERFAMILY	SSF53659	Isocitrate/Isopropylmalate dehydrogenase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A9Q4RPB2	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_06213	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.573