Protein profile

KP13_04036

Gp18 phage protein

Genome: KpKP13

Gene: AHE45164.1 Structure source: AlphaFold + ColabFold UniProt A0AAX2BR70
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Amino acids 236
Annotations 3
Features 17
PDB binders 0
Druggability 0.966

Overview

Basic information about this protein and its source genome.

Accession
KP13_04036
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45164.1
Status
annotated
Amino acids
236
Structure source
AlphaFold + ColabFold
GO
GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0005515 Binding to a protein. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.966
Structure A0AAX2BR70
Pocket Pocket 1
P2Rank 0.313
Structure A0AAX2BR70
Pocket Pocket 1
ColabFold model
FPocket 0.926 · Pocket 1
P2Rank 0.258 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 36 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0005515 Binding to a protein.
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
113 235 Gene3D G3DSA:3.90.1720.10 endopeptidase domain like (from Nostoc punctiforme)
2 170 PANTHER PTHR34858 CYSO-CYSTEINE PEPTIDASE
2 102 SUPERFAMILY SSF102712 JAB1/MPN domain
1 120 ProSiteProfiles PS50249 MPN domain profile.
1 120 InterPro IPR037518 MPN domain
1 109 Gene3D G3DSA:3.40.140.10 Cytidine Deaminase, domain 2
117 231 Pfam PF00877 NlpC/P60 family
117 231 InterPro IPR000064 Endopeptidase, NLPC/P60 domain
112 233 SUPERFAMILY SSF54001 Cysteine proteinases
112 233 InterPro IPR038765 Papain-like cysteine peptidase superfamily
96 233 ProSiteProfiles PS51935 NlpC/P60 domain profile.
96 233 InterPro IPR000064 Endopeptidase, NLPC/P60 domain
3 100 Pfam PF14464 Prokaryotic homologs of the JAB domain
3 100 InterPro IPR028090 JAB domain, prokaryotic
1 124 SMART SM00232 pad1_6
1 124 InterPro IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
4 111 CDD cd08073 MPN_NLPC_P60

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0AAX2BR70
AlphaFold — — full sequence — Viewing
ColabFold KP13_04036
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.966

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.93 0.222
2 4.88 0.219
3 4.78 0.211
4 4.65 0.202
5 3.4 0.122