Protein profile

KP13_04024

Peptidase S49

Genome: KpKP13

Gene: AHE45176.1 Structure source: AlphaFold + ColabFold UniProt A0AAX2BQX1
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Amino acids 306
Annotations 2
Features 8
PDB binders 0
Druggability 0.933

Overview

Basic information about this protein and its source genome.

Accession
KP13_04024
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45176.1
Status
annotated
Amino acids
306
Structure source
AlphaFold + ColabFold
GO
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.933
Structure A0AAX2BQX1
Pocket Pocket 8
P2Rank 0.757
Structure A0AAX2BQX1
Pocket Pocket 1
ColabFold model
FPocket 0.945 · Pocket 25
P2Rank 0.792 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
138 282 Pfam PF01343 Peptidase family S49
138 282 InterPro IPR002142 Peptidase S49
61 272 SUPERFAMILY SSF52096 ClpP/crotonase
61 272 InterPro IPR029045 ClpP/crotonase-like domain superfamily
67 281 CDD cd07022 S49_Sppa_36K_type
67 281 InterPro IPR033855 Bacteriophage protein C
67 291 PANTHER PTHR33209 PROTEASE 4
61 306 Gene3D G3DSA:3.90.226.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0AAX2BQX1
AlphaFold — — full sequence — Viewing
ColabFold KP13_04024
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.933

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.31 0.605
2 2.51 0.07
3 1.25 0.012
4 0.84 0.003