Protein profile

KP13_04021

Putative terminase large subunit

Genome: KpKP13

Gene: AHE45179.1 Structure source: AlphaFold + ColabFold UniProt A0A330ZTM7
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Amino acids 573
Annotations 1
Features 8
PDB binders 0
Druggability 0.44

Overview

Basic information about this protein and its source genome.

Accession
KP13_04021
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45179.1
Status
annotated
Amino acids
573
Structure source
AlphaFold + ColabFold
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.44
Structure A0A330ZTM7
Pocket Pocket 7
P2Rank 0.784
Structure A0A330ZTM7
Pocket Pocket 1
ColabFold model
FPocket 0.462 · Pocket 22
P2Rank 0.788 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
269 556 Pfam PF20441 Terminase large subunit, endonuclease domain
269 556 InterPro IPR046462 Terminase large subunit-like, endonuclease domain
33 257 Gene3D G3DSA:3.40.50.300 -
33 257 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 562 PANTHER PTHR41287 -
1 562 InterPro IPR005021 Terminase large subunit-like
85 253 Pfam PF03354 Terminase large subunit, ATPase domain
85 253 InterPro IPR046461 Terminase large subunit-like, ATPase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A330ZTM7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04021
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.44
10 0.361

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.61 0.517
2 3.35 0.119
3 2.41 0.064
4 2.33 0.06
5 1.36 0.016