Protein profile

KP13_31968

HNH endonuclease domain-containing protein

Genome: KpKP13

Gene: AHE45183.1 Structure source: AlphaFold + ColabFold UniProt A0A210UNI2
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Amino acids 120
Annotations 5
Features 8
PDB binders 0
Druggability 0.092

Overview

Basic information about this protein and its source genome.

Accession
KP13_31968
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45183.1
Status
annotated
Amino acids
120
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0008270 Binding to a zinc ion (Zn). GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
82.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.092
Structure A0A210UNI2
Pocket Pocket 1
P2Rank 0.007
Structure A0A210UNI2
Pocket Pocket 1
ColabFold model
FPocket 0.213 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003676 Binding to a nucleic acid.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
29 115 PANTHER PTHR41286 HNH NUCLEASE YAJD-RELATED
57 111 SMART SM00507 HNH_5
57 111 InterPro IPR003615 HNH nuclease
56 114 CDD cd00085 HNHc
56 114 InterPro IPR003615 HNH nuclease
28 120 Gene3D G3DSA:1.10.30.50 -
70 115 Pfam PF01844 HNH endonuclease
70 115 InterPro IPR002711 HNH endonuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A210UNI2
AlphaFold — — full sequence — Viewing
ColabFold KP13_31968
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer