Protein profile

KP13_04011

Lysis protein S from lambdoid prophage Qin

Genome: KpKP13

Gene: AHE45191.1 essQ Structure source: AlphaFold + ColabFold UniProt A0A1S8Y3K1

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Amino acids 71

Annotations 2

Features 11

PDB binders 0

Druggability 0.38

Overview

Basic information about this protein and its source genome.

Accession: KP13_04011
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE45191.1 essQ
Status: annotated
Amino acids: 71
Structure source: AlphaFold + ColabFold

GO:0001907 A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. GO:0140911 An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 91.549
DEG E-value: 8.17e-44
Localization: Unknown
ColabFold pLDDT: 82.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.38

Structure A0A1S8Y3K1

Pocket Pocket 2

P2Rank

Structure A0A1S8Y3K1

Pocket No pockets

ColabFold model

FPocket 0.601 · Pocket 1

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 27 / 4744 genomes with a hit

Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0001907 A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0140911 An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
5	67	Pfam	PF04971	Bacteriophage P21 holin S
5	67	InterPro	IPR007054	Lysis protein S
7	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
26	36	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
37	58	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
59	71	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	71	PIRSF	PIRSF030786	Lysis_prot_S
1	71	InterPro	IPR007054	Lysis protein S
36	58	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	25	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	6	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A1S8Y3K1	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04011	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.38

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.601