Protein profile

KP13_04853

DNA-binding protein

Genome: KpKP13

Gene: AHE45211.1 Structure source: AlphaFold + ColabFold UniProt W9B7F0
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Amino acids 129
Annotations 1
Features 13
PDB binders 0
Druggability 0.516

Overview

Basic information about this protein and its source genome.

Accession
KP13_04853
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45211.1
Status
annotated
Amino acids
129
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.303
DEG E-value
5.71e-45
Localization
Unknown
ColabFold pLDDT
92.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.516
Structure W9B7F0
Pocket Pocket 4
P2Rank
Structure W9B7F0
Pocket No pockets
ColabFold model
FPocket 0.929 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
20 67 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
20 67 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
16 69 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
16 69 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
16 67 CDD cd00093 HTH_XRE
16 67 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
10 67 SMART SM00530 mbf_short4
10 67 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
19 67 Pfam PF01381 Helix-turn-helix
19 67 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 21 Coils Coil Coil
5 74 Gene3D G3DSA:1.10.260.40 -
5 74 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W9B7F0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04853
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.516