Protein profile

KP13_04857

Exodeoxyribonuclease 8

Genome: KpKP13

Gene: recE AHE45217.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EM29
Export view
Amino acids 712
Annotations 3
Features 9
PDB binders 0
Druggability 0.369

Overview

Basic information about this protein and its source genome.

Accession
KP13_04857
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
recE AHE45217.1
Status
annotated
Amino acids
712
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0051908 Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. GO:0090305 OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
79.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.369
Structure A0A6A8EM29
Pocket Pocket 49
P2Rank 0.654
Structure A0A6A8EM29
Pocket Pocket 1
ColabFold model
FPocket 0.652 · Pocket 5
P2Rank 0.69 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003676 Binding to a nucleic acid.
  • GO:0051908 Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule.
  • GO:0090305 OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
56 178 Pfam PF06630 Enterobacterial exodeoxyribonuclease VIII
56 178 InterPro IPR010584 Exodeoxyribonuclease 8
519 696 Pfam PF16473 3'-5' exoribonuclease Rv2179c-like domain
519 696 InterPro IPR033390 3'-5' exoribonuclease Rv2179c-like domain
94 125 MobiDBLite mobidb-lite consensus disorder prediction
515 700 Gene3D G3DSA:3.30.420.10 -
515 700 InterPro IPR036397 Ribonuclease H superfamily
517 698 SUPERFAMILY SSF53098 Ribonuclease H-like
517 698 InterPro IPR012337 Ribonuclease H-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EM29
AlphaFold — — full sequence — Viewing
ColabFold KP13_04857
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
49 0.369

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.46 0.508
2 7.14 0.371
3 3.55 0.131
4 1.83 0.035