Protein profile

KP13_04858

Excisionase-like protein from lambdoid prophage 14

Genome: KpKP13

Gene: xisE AHE45218.1 Structure source: AlphaFold + ColabFold UniProt A0A486UQY5

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Amino acids 89

Annotations 2

Features 6

PDB binders 0

Druggability 0.269

Overview

Basic information about this protein and its source genome.

Accession: KP13_04858
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: xisE AHE45218.1
Status: annotated
Amino acids: 89
Structure source: AlphaFold + ColabFold

GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: Unknown
ColabFold pLDDT: 75.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.269

Structure A0A486UQY5

Pocket Pocket 2

P2Rank

Structure A0A486UQY5

Pocket No pockets

ColabFold model

FPocket 0.148 · Pocket 1

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 8 / 4744 genomes with a hit

Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
11	88	Gene3D	G3DSA:1.10.1660.20	-
11	88	InterPro	IPR038137	Excisionase-like superfamily
13	83	Pfam	PF07825	Excisionase-like protein
13	83	InterPro	IPR012884	Excisionase-like
12	87	SUPERFAMILY	SSF46955	Putative DNA-binding domain
12	87	InterPro	IPR009061	Putative DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A486UQY5	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04858	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.269