Protein profile

KP13_04859

Prophage lambda integrase

Genome: KpKP13

Gene: AHE45219.1 intE Structure source: ColabFold
Export view
Amino acids 375
Annotations 4
Features 18
PDB binders 0
Druggability 0.358

Overview

Basic information about this protein and its source genome.

Accession
KP13_04859
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45219.1 intE
Status
annotated
Amino acids
375
Structure source
ColabFold
GO
GO:0008907 Catalysis of the integration of one DNA segment into another. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.416
DEG E-value
5.73e-168
Localization
Unknown
ColabFold pLDDT
91.86

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.358
Structure CB_KP13_04859
Pocket Pocket 9
P2Rank 0.136
Structure CB_KP13_04859
Pocket Pocket 1
ColabFold model
FPocket 0.358 · Pocket 9
P2Rank 0.136 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 28 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008907 Catalysis of the integration of one DNA segment into another.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 72 Pfam PF09003 Bacteriophage lambda integrase, Arm DNA-binding domain
1 72 InterPro IPR015094 Integrase, lambda-type, N-terminal DNA-binding
198 371 CDD cd00800 INT_Lambda_C
82 167 ProSiteProfiles PS51900 Core-binding (CB) domain profile.
82 167 InterPro IPR044068 Core-binding (CB) domain
189 375 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
189 375 InterPro IPR002104 Integrase, catalytic domain
82 189 Gene3D G3DSA:1.10.150.130 -
82 189 InterPro IPR010998 Integrase/recombinase, N-terminal
193 364 Pfam PF00589 Phage integrase family
193 364 InterPro IPR002104 Integrase, catalytic domain
1 68 Gene3D G3DSA:3.30.160.60 Classic Zinc Finger
191 375 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
191 375 InterPro IPR013762 Integrase-like, catalytic domain superfamily
86 374 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
86 374 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
17 60 SUPERFAMILY SSF54171 DNA-binding domain
17 60 InterPro IPR016177 DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_04859
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.358
1 0.258

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.02 0.099
2 1.09 0.007