Protein profile

KP13_04865

high frequency lysogenization protein hflD

Genome: KpKP13

Gene: hflD AHE45225.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLK8
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Amino acids 213
Annotations 2
Features 16
PDB binders 0
Druggability 0.561

Overview

Basic information about this protein and its source genome.

Accession
KP13_04865
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hflD AHE45225.1
Status
annotated
Amino acids
213
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
53.81
DEG E-value
1.8300000000000003e-73
Localization
Unknown
ColabFold pLDDT
94.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.561
Structure A0A0H3GLK8
Pocket Pocket 12
P2Rank 0.064
Structure A0A0H3GLK8
Pocket Pocket 1
ColabFold model
FPocket 0.358 · Pocket 1
P2Rank 0.098 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
7 199 Pfam PF04356 Protein of unknown function (DUF489)
7 199 InterPro IPR007451 High frequency lysogenization protein HflD
1 210 SUPERFAMILY SSF101322 YcfC-like
1 210 InterPro IPR035932 HflD-like superfamily
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 213 FunFam G3DSA:1.10.3890.10:FF:000001 High frequency lysogenization protein HflD homolog
8 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 213 Gene3D G3DSA:1.10.3890.10 -
1 213 InterPro IPR035932 HflD-like superfamily
1 207 Hamap MF_00695 High frequency lysogenization protein HflD [hflD].
1 207 InterPro IPR007451 High frequency lysogenization protein HflD
19 213 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
1 208 PANTHER PTHR38100 HIGH FREQUENCY LYSOGENIZATION PROTEIN HFLD
1 208 InterPro IPR007451 High frequency lysogenization protein HflD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLK8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04865
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.049
2 0.034
13 0.0
17 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.67 0.064
2 1.46 0.016
3 1.23 0.01
4 0.93 0.004