Protein profile

KP13_04868

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE45228.1 Structure source: AlphaFold + ColabFold UniProt W8VHC6
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Amino acids 363
Annotations 3
Features 16
PDB binders 0
Druggability 0.75

Overview

Basic information about this protein and its source genome.

Accession
KP13_04868
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45228.1
Status
annotated
Amino acids
363
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
79.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.75
Structure W8VHC6
Pocket Pocket 1
P2Rank 0.904
Structure W8VHC6
Pocket Pocket 1
ColabFold model
FPocket 0.323 · Pocket 29
P2Rank 0.672 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
263 360 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
263 360 InterPro IPR018060 DNA binding HTH domain, AraC-type
283 359 Pfam PF12833 Helix-turn-helix domain
283 359 InterPro IPR018060 DNA binding HTH domain, AraC-type
276 358 SMART SM00342 aracneu4
276 358 InterPro IPR018060 DNA binding HTH domain, AraC-type
260 362 Gene3D G3DSA:1.10.10.60 -
98 361 PANTHER PTHR46796 HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
115 240 Pfam PF02311 AraC-like ligand binding domain
115 240 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
260 309 SUPERFAMILY SSF46689 Homeodomain-like
260 309 InterPro IPR009057 Homeobox-like domain superfamily
118 226 SUPERFAMILY SSF51215 Regulatory protein AraC
118 226 InterPro IPR037923 Transcription regulator HTH-like
312 360 SUPERFAMILY SSF46689 Homeodomain-like
312 360 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8VHC6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04868
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.75

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.94 0.885
2 2.41 0.065
3 1.01 0.006