Protein profile

KP13_04874

Spermidine/putrescine transport system permease protein potB

Genome: KpKP13

Gene: potB AHE45234.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRK8
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Amino acids 285
Annotations 2
Features 31
PDB binders 0
Druggability 0.615

Overview

Basic information about this protein and its source genome.

Accession
KP13_04874
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
potB AHE45234.1
Status
annotated
Amino acids
285
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.615
Structure A0A0H3GRK8
Pocket Pocket 2
P2Rank 0.029
Structure A0A0H3GRK8
Pocket Pocket 1
ColabFold model
FPocket 0.94 · Pocket 1
P2Rank 0.015 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 134 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
83 282 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
83 282 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
194 216 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
250 272 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
225 251 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 277 PANTHER PTHR42929 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCU-RELATED-RELATED
98 120 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
125 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
198 224 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
252 272 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 274 SUPERFAMILY SSF161098 MetI-like
6 274 InterPro IPR035906 MetI-like superfamily
144 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
151 173 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 279 FunFam G3DSA:1.10.3720.10:FF:000029 Spermidine/putrescine ABC transporter permease PotB
65 271 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
65 271 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
100 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
273 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
89 99 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 197 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
37 63 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
64 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 278 Gene3D G3DSA:1.10.3720.10 -
6 278 InterPro IPR035906 MetI-like superfamily
65 264 CDD cd06261 TM_PBP2
65 264 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRK8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04874
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.615
5 0.17
8 0.082
1 0.004

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.82 0.029
2 1.44 0.016
3 1.42 0.015
4 1.24 0.01
5 1.04 0.006