Protein profile

KP13_04877

Aldehyde dehydrogenase

Genome: KpKP13

Gene: AHE45237.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMW7
Export view
Amino acids 574
Annotations 2
Features 11
PDB binders 0
Druggability 0.836

Overview

Basic information about this protein and its source genome.

Accession
KP13_04877
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45237.1
Status
annotated
Amino acids
574
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.836
Structure A0A0H3GMW7
Pocket Pocket 3
P2Rank 0.952
Structure A0A0H3GMW7
Pocket Pocket 1
ColabFold model
FPocket 0.986 · Pocket 31
P2Rank 0.956 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0016620 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
7 76 SUPERFAMILY SSF53720 ALDH-like
7 76 InterPro IPR016161 Aldehyde/histidinol dehydrogenase
5 323 Gene3D G3DSA:3.40.605.10 Aldehyde Dehydrogenase; Chain A, domain 1
5 323 InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
376 514 Gene3D G3DSA:3.40.309.10 Aldehyde Dehydrogenase; Chain A, domain 2
376 514 InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
189 487 SUPERFAMILY SSF53720 ALDH-like
189 487 InterPro IPR016161 Aldehyde/histidinol dehydrogenase
205 331 PANTHER PTHR11699 ALDEHYDE DEHYDROGENASE-RELATED
220 333 Pfam PF00171 Aldehyde dehydrogenase family
220 333 InterPro IPR015590 Aldehyde dehydrogenase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMW7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04877
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
36 0.734
41 0.401
12 0.268

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 31.84 0.941
2 16.24 0.774
3 9.13 0.489
4 2.89 0.092
5 2.47 0.068