Protein profile

KP13_04881

Transaldolase 1

Genome: KpKP13

Gene: AHE45241.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EH43
Export view
Amino acids 317
Annotations 6
Features 18
PDB binders 11
Druggability 0.391

Overview

Basic information about this protein and its source genome.

Accession
KP13_04881
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45241.1
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
EC
2.2.1.2
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801 Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. GO:0006098 The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
58.209
Human E-value
1.05e-20
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
61.199
DEG E-value
2.1899999999999998e-141
Localization
Cytoplasmic
ColabFold pLDDT
97.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.391
Structure A0A6A8EH43
Pocket Pocket 1
P2Rank 0.609
Structure A0A6A8EH43
Pocket Pocket 1
ColabFold model
FPocket 0.423 · Pocket 4
P2Rank 0.629 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 187 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0004801 Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
  • GO:0006098 The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 317 FunFam G3DSA:3.20.20.70:FF:000002 Transaldolase
14 313 Pfam PF00923 Transaldolase/Fructose-6-phosphate aldolase
14 313 InterPro IPR001585 Transaldolase/Fructose-6-phosphate aldolase
129 146 ProSitePatterns PS00958 Transaldolase active site.
129 146 InterPro IPR018225 Transaldolase, active site
3 315 PANTHER PTHR10683 TRANSALDOLASE
3 315 InterPro IPR001585 Transaldolase/Fructose-6-phosphate aldolase
31 39 ProSitePatterns PS01054 Transaldolase signature 1.
31 39 InterPro IPR018225 Transaldolase, active site
3 316 NCBIfam TIGR00874 transaldolase
3 316 InterPro IPR004730 Transaldolase type 1
1 316 SUPERFAMILY SSF51569 Aldolase
3 313 CDD cd00957 Transaldolase_TalAB
3 313 InterPro IPR004730 Transaldolase type 1
2 317 Hamap MF_00492 Transaldolase [tal].
2 317 InterPro IPR004730 Transaldolase type 1
2 316 Gene3D G3DSA:3.20.20.70 Aldolase class I
2 316 InterPro IPR013785 Aldolase-type TIM barrel

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EH43
AlphaFold — — full sequence — Viewing
ColabFold KP13_04881
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.391

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.11 0.369
2 5.96 0.293
3 1.49 0.021

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

61 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
44S
4S2B
P0A870 244.1 Da LogP -2.08 TPSA 136.7 ✓ Ro5 ✓ Clean C1[C@H]([C@@H](O[C@H]1O)[C@@H](COP(=O)(O)O)O)O
4Y8
5ZOL
P78055 74.1 Da LogP -0.43 TPSA 37.3 ✓ Ro5 ✓ Clean CC(=O)CO
A5P
3UPB
Q5NFX0 232.1 Da LogP -2.83 TPSA 147.7 1 viol. ✓ Clean C([C@H]([C@@H]([C@@H](COP(=O)(O)O)O)O)O)O
E4P
3S1U
Q9HKI3 200.1 Da LogP -1.98 TPSA 124.3 ✓ Ro5 ✓ Clean C([C@H]([C@H](C=O)O)O)OP(=O)(O)O
F6R
4S2C
P0A870 260.1 Da LogP -3.26 TPSA 164.8 1 viol. ✓ Clean C([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)OP(=O)(O)O
FLC
3S1W
Q9HKI3 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
G3P
4XZ9
Q9HKI3 172.1 Da LogP -1.55 TPSA 107.2 ✓ Ro5 ✓ Clean C([C@H](COP(=O)(O)O)O)O
I22
3TKF
Q5NFX0 290.2 Da LogP -3.90 TPSA 185.0 1 viol. ✓ Clean C([C@H]([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)O)OP(=…
LW1
5ZOL
P78055 112.2 Da LogP 1.56 TPSA 17.1 ✓ Ro5 ✓ Clean c1cc(sc1)C=O
LW2
5ZOL
P78055 186.2 Da LogP 0.73 TPSA 57.5 ✓ Ro5 ✓ Clean CC(=O)[C@H]([C@@H](c1cccs1)O)O
P2D
4S1F
P78055 100.1 Da LogP 0.55 TPSA 34.1 ✓ Ro5 ✓ Clean CC(=O)CC(=O)C

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.