Protein profile

KP13_04883

Glucitol/sorbitol-specific phosphotransferase enzyme IIA component

Genome: KpKP13

Gene: AHE45243.1 Structure source: AlphaFold + ColabFold UniProt A0A0E1GVM8
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Amino acids 124
Annotations 4
Features 10
PDB binders 0
Druggability 0.12

Overview

Basic information about this protein and its source genome.

Accession
KP13_04883
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45243.1
Status
annotated
Amino acids
124
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982 Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
88.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.12
Structure A0A0E1GVM8
Pocket Pocket 2
P2Rank 0.016
Structure A0A0E1GVM8
Pocket Pocket 1
ColabFold model
FPocket 0.511 · Pocket 2
P2Rank 0.02 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
  • GO:0008982 Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
4 117 ProSiteProfiles PS51097 PTS_EIIA type-5 domain profile.
4 117 InterPro IPR004716 Phosphotransferase system, glucitol/sorbitol-specific IIA component
5 119 PANTHER PTHR40398 PTS SYSTEM GLUCITOL/SORBITOL-SPECIFIC EIIA COMPONENT
5 119 InterPro IPR004716 Phosphotransferase system, glucitol/sorbitol-specific IIA component
5 120 SUPERFAMILY SSF141530 PTSIIA/GutA-like
5 120 InterPro IPR036665 Phosphotransferase system, glucitol/sorbitol-specific IIA component superfamily
6 117 Pfam PF03829 PTS system glucitol/sorbitol-specific IIA component
6 117 InterPro IPR004716 Phosphotransferase system, glucitol/sorbitol-specific IIA component
3 123 Gene3D G3DSA:2.40.33.40 -
3 123 InterPro IPR036665 Phosphotransferase system, glucitol/sorbitol-specific IIA component superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0E1GVM8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04883
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer