Protein profile

KP13_04905

hypothetical protein

Genome: KpKP13

Gene: AHE45265.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR80
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Amino acids 187
Annotations 0
Features 11
PDB binders 0
Druggability 0.527

Overview

Basic information about this protein and its source genome.

Accession
KP13_04905
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45265.1
Status
annotated
Amino acids
187
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.111
DEG E-value
1.34e-128
Localization
Cytoplasmic
ColabFold pLDDT
92.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.527
Structure A0A0H3GR80
Pocket Pocket 1
P2Rank 0.418
Structure A0A0H3GR80
Pocket Pocket 1
ColabFold model
FPocket 0.882 · Pocket 1
P2Rank 0.519 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 115 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
8 186 FunFam G3DSA:3.40.50.1820:FF:000007 UPF0227 protein YcfP
8 183 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
8 183 InterPro IPR029058 Alpha/Beta hydrolase fold
7 186 PANTHER PTHR35602 ESTERASE YQIA-RELATED
7 186 InterPro IPR008886 Uncharacterised protein family UPF0227/Esterase YqiA
7 186 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
7 186 InterPro IPR029058 Alpha/Beta hydrolase fold
8 184 Pfam PF05728 Uncharacterised protein family (UPF0227)
8 184 InterPro IPR008886 Uncharacterised protein family UPF0227/Esterase YqiA
8 185 Hamap MF_01047 UPF0227 protein YcfP [ycfP].
8 185 InterPro IPR022987 Uncharacterised protein family UPF0227

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR80
AlphaFold — — full sequence — Viewing
ColabFold KP13_04905
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.527
6 0.003
4 0.001
14 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.1 0.418
2 3.04 0.08