Protein profile

KP13_04907

Thiamine kinase

Genome: KpKP13

Gene: thiK AHE45267.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLH3
Export view
Amino acids 262
Annotations 6
Features 7
PDB binders 0
Druggability 0.505

Overview

Basic information about this protein and its source genome.

Accession
KP13_04907
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
thiK AHE45267.1
Status
annotated
Amino acids
262
Structure source
AlphaFold + ColabFold
EC
2.7.1.89
GO
GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0019165 Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate. GO:0006772 The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009229 The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.505
Structure A0A0H3GLH3
Pocket Pocket 5
P2Rank 0.956
Structure A0A0H3GLH3
Pocket Pocket 1
ColabFold model
FPocket 0.78 · Pocket 1
P2Rank 0.937 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
  • GO:0019165 Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate.
  • GO:0006772 The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0009229 The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
23 249 SUPERFAMILY SSF56112 Protein kinase-like (PK-like)
23 249 InterPro IPR011009 Protein kinase-like domain superfamily
5 256 Hamap MF_01604 Thiamine kinase [thiK].
5 256 InterPro IPR014093 Thiamine kinase
18 205 Pfam PF01636 Phosphotransferase enzyme family
18 205 InterPro IPR002575 Aminoglycoside phosphotransferase
78 259 Gene3D G3DSA:3.90.1200.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLH3
AlphaFold — — full sequence — Viewing
ColabFold KP13_04907
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.505

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.34 0.88
2 6.93 0.358