Protein profile

KP13_04908

fibronectin-binding protein

Genome: KpKP13

Gene: AHE45268.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVJ1
Export view
Amino acids 215
Annotations 4
Features 21
PDB binders 0
Druggability 0.579

Overview

Basic information about this protein and its source genome.

Accession
KP13_04908
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45268.1
Status
annotated
Amino acids
215
Structure source
AlphaFold + ColabFold
GO
GO:0031241 The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0030234 A molecular function regulator that modulates a catalytic activity. GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008360 Any process that modulates the surface configuration of a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
77.27

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.579
Structure A0A0H3GVJ1
Pocket Pocket 1
P2Rank 0.021
Structure A0A0H3GVJ1
Pocket Pocket 1
ColabFold model
FPocket 0.092 · Pocket 5
P2Rank 0.006 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 72 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0031241 The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it.
  • GO:0030234 A molecular function regulator that modulates a catalytic activity.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
  • GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
80 215 Gene3D G3DSA:3.40.50.10610 -
76 211 Pfam PF13036 Peptidoglycan-synthase activator LpoB
76 211 InterPro IPR014094 Penicillin-binding protein activator LpoB
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
80 215 FunFam G3DSA:3.40.50.10610:FF:000002 Penicillin-binding protein activator LpoB
4 213 Hamap MF_01889 Penicillin-binding protein activator LpoB [lpoB].
4 213 InterPro IPR014094 Penicillin-binding protein activator LpoB
33 58 MobiDBLite mobidb-lite consensus disorder prediction
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 215 PANTHER PTHR40593 PENICILLIN-BINDING PROTEIN ACTIVATOR LPOB
1 215 InterPro IPR014094 Penicillin-binding protein activator LpoB
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
25 215 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
28 78 MobiDBLite mobidb-lite consensus disorder prediction
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
6 214 NCBIfam TIGR02722 penicillin-binding protein activator LpoB
6 214 InterPro IPR014094 Penicillin-binding protein activator LpoB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVJ1
AlphaFold — — full sequence — Viewing
ColabFold KP13_04908
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.579
9 0.003
11 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.61 0.021
2 1.42 0.015