Protein profile

KP13_04915

hypothetical protein

Genome: KpKP13

Gene: AHE45275.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR71
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Amino acids 340
Annotations 6
Features 21
PDB binders 0
Druggability 0.631

Overview

Basic information about this protein and its source genome.

Accession
KP13_04915
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45275.1
Status
annotated
Amino acids
340
Structure source
AlphaFold + ColabFold
EC
4.2.2.29
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0008932 Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.006
DEG E-value
1.26e-131
Localization
Unknown
ColabFold pLDDT
94.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.631
Structure A0A0H3GR71
Pocket Pocket 1
P2Rank 0.138
Structure A0A0H3GR71
Pocket Pocket 1
ColabFold model
FPocket 0.563 · Pocket 1
P2Rank 0.255 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0008932 Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
72 109 Gene3D G3DSA:3.30.160.60 Classic Zinc Finger
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
82 327 CDD cd08010 MltG_like
82 327 InterPro IPR003770 Endolytic murein transglycosylase
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
43 328 Pfam PF02618 YceG-like family
43 328 InterPro IPR003770 Endolytic murein transglycosylase
7 332 Hamap MF_02065 Endolytic murein transglycosylase [mltG].
7 332 InterPro IPR003770 Endolytic murein transglycosylase
1 20 SignalP_EUK SignalP-TM SignalP-TM
303 338 FunFam G3DSA:3.30.160.60:FF:000242 Endolytic murein transglycosylase
72 109 FunFam G3DSA:3.30.160.60:FF:000497 Endolytic murein transglycosylase
21 340 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 333 PANTHER PTHR30518 UNCHARACTERIZED
2 333 InterPro IPR003770 Endolytic murein transglycosylase
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
302 340 Gene3D G3DSA:3.30.160.60 Classic Zinc Finger
7 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 337 NCBIfam TIGR00247 endolytic transglycosylase MltG
1 337 InterPro IPR003770 Endolytic murein transglycosylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR71
AlphaFold — — full sequence — Viewing
ColabFold KP13_04915
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.631
4 0.004
6 0.001
14 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.14 0.138
2 2.74 0.067
3 2.51 0.057
4 1.55 0.019