Protein profile

KP13_04922

Phosphate acyltransferase

Genome: KpKP13

Gene: plsX AHE45282.1 Structure source: AlphaFold + ColabFold UniProt A6T7F0
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Amino acids 347
Annotations 3
Features 13
PDB binders 0
Druggability 0.905

Overview

Basic information about this protein and its source genome.

Accession
KP13_04922
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
plsX AHE45282.1
Status
annotated
Amino acids
347
Structure source
AlphaFold + ColabFold
GO
GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.207
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
85.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.905
Structure A6T7F0
Pocket Pocket 4
P2Rank 0.383
Structure A6T7F0
Pocket Pocket 1
ColabFold model
FPocket 0.898 · Pocket 1
P2Rank 0.82 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 325 FunFam G3DSA:3.40.718.10:FF:000008 Phosphate acyltransferase
2 322 SUPERFAMILY SSF53659 Isocitrate/Isopropylmalate dehydrogenase-like
1 325 Gene3D G3DSA:3.40.718.10 Isopropylmalate Dehydrogenase
1 327 Hamap MF_00019 Phosphate acyltransferase [plsX].
1 327 InterPro IPR012281 Phospholipid biosynthesis protein, PlsX-like
2 313 Pfam PF02504 Fatty acid synthesis protein
2 313 InterPro IPR003664 Fatty acid synthesis PlsX protein
2 321 PANTHER PTHR30100 FATTY ACID/PHOSPHOLIPID SYNTHESIS PROTEIN PLSX
2 321 InterPro IPR012281 Phospholipid biosynthesis protein, PlsX-like
1 325 PIRSF PIRSF002465 Phsphlp_syn_PlsX
1 325 InterPro IPR012281 Phospholipid biosynthesis protein, PlsX-like
2 327 NCBIfam TIGR00182 phosphate acyltransferase PlsX
2 327 InterPro IPR012281 Phospholipid biosynthesis protein, PlsX-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A6T7F0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04922
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.905
9 0.585

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.56 0.132
2 2.0 0.043
3 1.6 0.025
4 0.94 0.004