Protein profile

KP13_04923

hypothetical protein

Genome: KpKP13

Gene: AHE45283.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMS9

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Amino acids 173

Annotations 2

Features 4

PDB binders 0

Druggability 0.364

Overview

Basic information about this protein and its source genome.

Accession: KP13_04923
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE45283.1
Status: annotated
Amino acids: 173
Structure source: AlphaFold + ColabFold

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042254 A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 91.908
DEG E-value: 6.82e-118
Localization: Cytoplasmic
ColabFold pLDDT: 88.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.364

Structure A0A0H3GMS9

Pocket Pocket 4

P2Rank

Structure A0A0H3GMS9

Pocket No pockets

ColabFold model

FPocket 0.364 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 127 / 4744 genomes with a hit

Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0042254 A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records

Show feature table

Start	End	DB	Term	Name
62	171	Pfam	PF02620	Large ribosomal RNA subunit accumulation protein YceD
62	171	InterPro	IPR003772	Large ribosomal RNA subunit accumulation protein YceD
1	173	PANTHER	PTHR38099	LARGE RIBOSOMAL RNA SUBUNIT ACCUMULATION PROTEIN YCED
1	173	InterPro	IPR039255	Large ribosomal RNA subunit accumulation protein YceD, bacteria

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GMS9	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04923	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.364

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.364