Protein profile

KP13_04929

Virulence factor mviN

Genome: KpKP13

Gene: mviN AHE45292.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRG5
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Amino acids 511
Annotations 6
Features 65
PDB binders 2
Druggability 0.789

Overview

Basic information about this protein and its source genome.

Accession
KP13_04929
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mviN AHE45292.1
Status
annotated
Amino acids
511
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015648 Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0034204 The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008360 Any process that modulates the surface configuration of a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.585
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.789
Structure A0A0H3GRG5
Pocket Pocket 26
P2Rank 0.949
Structure A0A0H3GRG5
Pocket Pocket 1
ColabFold model
FPocket 0.845 · Pocket 27
P2Rank 0.932 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 137 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015648 Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0034204 The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
  • GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

65 records
Show feature table
Start End DB Term Name
130 152 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
186 203 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
407 429 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
349 371 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
274 296 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 110 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
348 370 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 511 PIRSF PIRSF002869 MviN
1 511 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
130 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
237 259 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
408 429 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
236 259 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
441 466 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
383 402 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
330 348 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
159 181 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
183 187 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 467 Hamap MF_02078 Probable lipid II flippase MurJ [murJ].
3 467 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
260 270 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
502 511 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
383 402 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
111 129 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
289 308 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
430 440 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
28 478 Pfam PF03023 Lipid II flippase MurJ
28 478 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
46 81 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
26 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 509 PANTHER PTHR47019 LIPID II FLIPPASE MURJ
403 407 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
478 501 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
161 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
155 160 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
11 431 CDD cd13123 MATE_MurJ_like
11 431 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
372 382 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
441 463 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 235 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
271 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
309 328 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
309 329 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
33 52 PRINTS PR01806 Virulence factor MviN signature
33 52 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
357 376 PRINTS PR01806 Virulence factor MviN signature
357 376 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
409 426 PRINTS PR01806 Virulence factor MviN signature
409 426 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
52 68 PRINTS PR01806 Virulence factor MviN signature
52 68 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
259 285 PRINTS PR01806 Virulence factor MviN signature
259 285 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
133 157 PRINTS PR01806 Virulence factor MviN signature
133 157 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
157 178 PRINTS PR01806 Virulence factor MviN signature
157 178 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
2 508 NCBIfam TIGR01695 murein biosynthesis integral membrane protein MurJ
2 508 InterPro IPR004268 Peptidoglycan biosynthesis protein MurJ
188 205 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
467 477 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
88 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 45 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
478 500 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRG5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04929
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
26 0.789
8 0.436
16 0.337
28 0.281

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.52 0.881
2 16.59 0.781
3 8.24 0.439
4 7.94 0.422
5 3.31 0.116

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
OLB
5T77
B7IE18 356.5 Da LogP 4.92 TPSA 66.8 ✓ Ro5 ✓ Clean CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](CO)O
OLC
5T77
B7IE18 356.5 Da LogP 4.92 TPSA 66.8 ✓ Ro5 ✓ Clean CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](CO)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.