Protein profile

KP13_04945

hypothetical protein

Genome: KpKP13

Gene: AHE45307.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVF2
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Amino acids 77
Annotations 0
Features 13
PDB binders 0
Druggability 0.722

Overview

Basic information about this protein and its source genome.

Accession
KP13_04945
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45307.1
Status
annotated
Amino acids
77
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
81.333
DEG E-value
1.3599999999999999e-42
Localization
Unknown
ColabFold pLDDT
71.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.722
Structure A0A0H3GVF2
Pocket Pocket 1
P2Rank 0.066
Structure A0A0H3GVF2
Pocket Pocket 1
ColabFold model
FPocket 0.605 · Pocket 2
P2Rank 0.294 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 SignalP_EUK SignalP-TM SignalP-TM
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 70 Pfam PF07119 Protein of unknown function (DUF1375)
51 70 InterPro IPR010780 Protein of unknown function DUF1375
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
47 69 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 18 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
24 46 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
70 77 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVF2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04945
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.722

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.01 0.043