Protein profile

KP13_04946

Glucans biosynthesis glucosyltransferase H

Genome: KpKP13

Gene: mdoH AHE45308.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMR0
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Amino acids 842
Annotations 4
Features 34
PDB binders 0
Druggability 0.982

Overview

Basic information about this protein and its source genome.

Accession
KP13_04946
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mdoH AHE45308.1
Status
annotated
Amino acids
842
Structure source
AlphaFold + ColabFold
EC
2.4.1.-
GO
GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009250 The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.982
Structure A0A0H3GMR0
Pocket Pocket 61
P2Rank 0.987
Structure A0A0H3GMR0
Pocket Pocket 1
ColabFold model
FPocket 0.846 · Pocket 67
P2Rank 0.982 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 101 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009250 The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
566 590 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
534 565 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
707 842 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
194 216 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
591 596 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
237 468 FunFam G3DSA:3.90.550.10:FF:000047 Glucans biosynthesis glucosyltransferase H
238 468 Gene3D G3DSA:3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
238 468 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
222 511 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
512 533 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
188 221 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
622 640 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
139 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
677 681 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
680 702 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
597 616 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
660 676 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
641 659 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
512 534 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
49 827 PANTHER PTHR43867 CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]
568 590 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
682 706 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
244 497 CDD cd04191 Glucan_BSP_MdoH
244 532 SUPERFAMILY SSF53448 Nucleotide-diphospho-sugar transferases
244 532 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
63 745 Hamap MF_01072 Glucans biosynthesis glucosyltransferase H [mdoH].
63 745 InterPro IPR023725 Glucan biosynthesis glucosyltransferase H
603 625 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
246 428 Pfam PF00535 Glycosyl transferase family 2
246 428 InterPro IPR001173 Glycosyltransferase 2-like
1 138 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
617 621 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
139 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
157 187 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMR0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04946
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
61 0.982
58 0.838
59 0.803
49 0.661

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 45.54 0.973
2 43.63 0.97
3 6.37 0.321
4 5.11 0.234
5 4.91 0.221