Protein profile

KP13_04950

HTH-type transcriptional regulator betI

Genome: KpKP13

Gene: AHE45312.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLD5
Export view
Amino acids 197
Annotations 3
Features 12
PDB binders 0
Druggability 0.186

Overview

Basic information about this protein and its source genome.

Accession
KP13_04950
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45312.1
Status
annotated
Amino acids
197
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.186
Structure A0A0H3GLD5
Pocket Pocket 13
P2Rank 0.908
Structure A0A0H3GLD5
Pocket Pocket 1
ColabFold model
FPocket 0.736 · Pocket 14
P2Rank 0.933 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
17 63 Pfam PF00440 Bacterial regulatory proteins, tetR family
17 63 InterPro IPR001647 DNA-binding HTH domain, TetR-type
5 189 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
6 75 SUPERFAMILY SSF46689 Homeodomain-like
6 75 InterPro IPR009057 Homeobox-like domain superfamily
7 171 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
38 61 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
38 61 InterPro IPR001647 DNA-binding HTH domain, TetR-type
17 30 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
17 30 InterPro IPR001647 DNA-binding HTH domain, TetR-type
11 71 ProSiteProfiles PS50977 TetR-type HTH domain profile.
11 71 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLD5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04950
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.92 0.667
2 3.56 0.131
3 1.49 0.021