Protein profile

KP13_04954

hypothetical protein

Genome: KpKP13

Gene: AHE45316.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRB9
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Amino acids 245
Annotations 5
Features 12
PDB binders 0
Druggability 0.344

Overview

Basic information about this protein and its source genome.

Accession
KP13_04954
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45316.1
Status
annotated
Amino acids
245
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
82.857
DEG E-value
2.78e-149
Localization
Cytoplasmic
ColabFold pLDDT
97.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.344
Structure A0A0H3GRB9
Pocket Pocket 5
P2Rank 0.663
Structure A0A0H3GRB9
Pocket Pocket 1
ColabFold model
FPocket 0.554 · Pocket 1
P2Rank 0.719 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
  • GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
4 78 SMART SM00481 npolultra
4 78 InterPro IPR003141 Polymerase/histidinol phosphatase, N-terminal
2 234 CDD cd07437 PHP_HisPPase_Ycdx_like
2 237 PANTHER PTHR36928 PHOSPHATASE YCDX-RELATED
5 78 Pfam PF02811 PHP domain
5 78 InterPro IPR004013 PHP domain
1 243 Hamap MF_01561 Probable phosphatase YcdX [ycdX].
1 243 InterPro IPR023710 Probable phosphatase YcdX
1 245 FunFam G3DSA:3.20.20.140:FF:000008 Probable phosphatase YcdX
1 245 Gene3D G3DSA:3.20.20.140 -
3 239 SUPERFAMILY SSF89550 PHP domain-like
3 239 InterPro IPR016195 Polymerase/histidinol phosphatase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRB9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04954
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.344

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.37 0.608
2 2.12 0.049