Protein profile

KP13_03934

Transcriptional regulator, LysR family

Genome: KpKP13

Gene: AHE45321.1 Structure source: ColabFold
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Amino acids 192
Annotations 0
Features 6
PDB binders 0
Druggability 0.381

Overview

Basic information about this protein and its source genome.

Accession
KP13_03934
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45321.1
Status
annotated
Amino acids
192
Structure source
ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.128
DEG E-value
2.02e-59
Localization
Cytoplasmic
ColabFold pLDDT
91.74

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.381
Structure CB_KP13_03934
Pocket Pocket 18
P2Rank 0.168
Structure CB_KP13_03934
Pocket Pocket 1
ColabFold model
FPocket 0.381 · Pocket 18
P2Rank 0.168 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 67 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 182 Gene3D G3DSA:3.40.190.10 -
2 186 PANTHER PTHR30537 HTH-TYPE TRANSCRIPTIONAL REGULATOR
1 185 Pfam PF03466 LysR substrate binding domain
1 185 InterPro IPR005119 LysR, substrate-binding
52 156 Gene3D G3DSA:3.40.190.10 -
2 189 SUPERFAMILY SSF53850 Periplasmic binding protein-like II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_03934
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.355
19 0.229

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.42 0.065