Protein profile

KP13_31918

Protein phoH

Genome: KpKP13

Gene: AHE45324.1 phoH Structure source: AlphaFold + ColabFold UniProt A0A2W0QUL5
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Amino acids 352
Annotations 2
Features 9
PDB binders 0
Druggability 0.312

Overview

Basic information about this protein and its source genome.

Accession
KP13_31918
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45324.1 phoH
Status
annotated
Amino acids
352
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
70.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.312
Structure A0A2W0QUL5
Pocket Pocket 2
P2Rank 0.439
Structure A0A2W0QUL5
Pocket Pocket 1
ColabFold model
FPocket 0.355 · Pocket 19
P2Rank 0.553 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 103 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
68 351 PANTHER PTHR30473 PROTEIN PHOH
147 351 Pfam PF02562 PhoH-like protein
147 351 InterPro IPR003714 PhoH-like protein
144 352 Gene3D G3DSA:3.40.50.300 -
144 352 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
146 329 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
146 329 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 20 MobiDBLite mobidb-lite consensus disorder prediction
144 352 FunFam G3DSA:3.40.50.300:FF:000455 Phosphate starvation-inducible ATPase PhoH

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2W0QUL5
AlphaFold — — full sequence — Viewing
ColabFold KP13_31918
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.312

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.8 0.213
2 1.24 0.012
3 1.03 0.006