Protein profile

KP13_03928

peptidase M75 family protein

Genome: KpKP13

Gene: AHE45326.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQZ2
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Amino acids 377
Annotations 1
Features 21
PDB binders 0
Druggability 0.483

Overview

Basic information about this protein and its source genome.

Accession
KP13_03928
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45326.1
Status
annotated
Amino acids
377
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
89.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.483
Structure A0A0H3GQZ2
Pocket Pocket 9
P2Rank 0.921
Structure A0A0H3GQZ2
Pocket Pocket 1
ColabFold model
FPocket 0.841 · Pocket 16
P2Rank 0.3 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 96 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
16 117 SUPERFAMILY SSF49503 Cupredoxins
16 117 InterPro IPR008972 Cupredoxin
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
130 377 Gene3D G3DSA:1.20.1420.20 M75 peptidase, HXXE motif
130 377 InterPro IPR038352 Imelysin-like domain superfamily
3 377 PANTHER PTHR39192 IRON UPTAKE SYSTEM COMPONENT EFEO
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
137 369 Pfam PF09375 Imelysin
137 369 InterPro IPR018976 Imelysin-like domain
1 28 SignalP_EUK SignalP-noTM SignalP-noTM
134 371 CDD cd14656 Imelysin-like_EfeO
134 371 InterPro IPR034981 EfeO/Algp7, imelysin-like domain
231 251 Coils Coil Coil
29 377 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
14 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
23 117 Gene3D G3DSA:2.60.40.420 -
23 117 InterPro IPR008972 Cupredoxin
15 117 Pfam PF13473 Cupredoxin-like domain
15 117 InterPro IPR028096 EfeO-type cupredoxin-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQZ2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03928
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.366
5 0.01
8 0.0
14 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 33.3 0.921
2 12.92 0.585
3 2.97 0.077