Protein profile

KP13_03927

Ferrous iron permease efeU

Genome: KpKP13

Gene: AHE45327.1 efeU Structure source: AlphaFold + ColabFold UniProt A0A0H3GRA7
Export view
Amino acids 276
Annotations 6
Features 30
PDB binders 0
Druggability 0.908

Overview

Basic information about this protein and its source genome.

Accession
KP13_03927
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45327.1 efeU
Status
annotated
Amino acids
276
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0033573 A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034755 A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. GO:0005381 Enables the transfer of iron (Fe) ions from one side of a membrane to the other. GO:0015093 Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
76.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.908
Structure A0A0H3GRA7
Pocket Pocket 21
P2Rank 0.921
Structure A0A0H3GRA7
Pocket Pocket 1
ColabFold model
FPocket 0.939 · Pocket 24
P2Rank 0.919 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0033573 A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0034755 A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
  • GO:0005381 Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
  • GO:0015093 Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
5 221 SUPERFAMILY SSF103473 MFS general substrate transporter
5 221 InterPro IPR036259 MFS transporter superfamily
70 89 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
248 264 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
265 276 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56 69 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
116 138 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
148 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
148 171 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
143 147 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 26 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 264 Pfam PF03239 Iron permease FTR1 family
1 264 InterPro IPR004923 Iron permease FTR1/Fip1/EfeU
1 269 NCBIfam TIGR00145 FTR1 family protein
1 269 InterPro IPR005217 Iron permease FTR1-like
70 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
33 55 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
117 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
177 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 270 PANTHER PTHR31632 IRON TRANSPORTER FTH1
4 270 InterPro IPR004923 Iron permease FTR1/Fip1/EfeU
183 203 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
172 182 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
204 247 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
248 265 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 55 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 116 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
27 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRA7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03927
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.908
23 0.854
25 0.3

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.39 0.898
2 8.14 0.433
3 3.22 0.111
4 2.07 0.046
5 0.7 0.001