Protein profile

KP13_03915

putative malonic semialdehyde reductase RutE

Genome: KpKP13

Gene: rutE AHE45339.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQX7
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Amino acids 196
Annotations 5
Features 11
PDB binders 0
Druggability 0.566

Overview

Basic information about this protein and its source genome.

Accession
KP13_03915
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rutE AHE45339.1
Status
annotated
Amino acids
196
Structure source
AlphaFold + ColabFold
EC
1.1.1.298
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0035527 Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. GO:0019740 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. GO:0006212 The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.566
Structure A0A0H3GQX7
Pocket Pocket 1
P2Rank 0.019
Structure A0A0H3GQX7
Pocket Pocket 1
ColabFold model
FPocket 0.527 · Pocket 9
P2Rank 0.007 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 68 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0035527 Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.
  • GO:0019740 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.
  • GO:0006212 The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
2 196 Hamap MF_01204 Probable malonic semialdehyde reductase RutE [rutE].
2 196 InterPro IPR023936 Probable malonic semialdehyde reductase RutE-like
5 194 Gene3D G3DSA:3.40.109.10 NADH Oxidase
5 194 InterPro IPR000415 Nitroreductase-like
7 102 PANTHER PTHR43543 MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED
13 192 SUPERFAMILY SSF55469 FMN-dependent nitroreductase-like
13 192 InterPro IPR000415 Nitroreductase-like
9 193 CDD cd02148 RutE-like
9 193 InterPro IPR023936 Probable malonic semialdehyde reductase RutE-like
16 174 Pfam PF00881 Nitroreductase family
16 174 InterPro IPR029479 Nitroreductase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQX7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03915
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.566
4 0.007
2 0.003
3 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.54 0.019