Protein profile

KP13_03907

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE45347.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GV95
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Amino acids 149
Annotations 1
Features 9
PDB binders 0
Druggability 0.532

Overview

Basic information about this protein and its source genome.

Accession
KP13_03907
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45347.1
Status
annotated
Amino acids
149
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.532
Structure A0A0H3GV95
Pocket Pocket 1
P2Rank
Structure A0A0H3GV95
Pocket No pockets
ColabFold model
FPocket 0.876 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 52 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 148 Gene3D G3DSA:1.10.10.10 -
1 148 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
6 143 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 143 InterPro IPR036390 Winged helix DNA-binding domain superfamily
11 108 ProSiteProfiles PS51118 HxlR-type HTH domain profile.
11 108 InterPro IPR002577 Helix-turn-helix, HxlR type
1 140 PANTHER PTHR33204 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
19 104 Pfam PF01638 HxlR-like helix-turn-helix
19 104 InterPro IPR002577 Helix-turn-helix, HxlR type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GV95
AlphaFold — — full sequence — Viewing
ColabFold KP13_03907
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.532
5 0.098
6 0.078
4 0.008