Protein profile

KP13_03900

HTH-type transcriptional regulator puuR

Genome: KpKP13

Gene: AHE45354.1 puuR Structure source: AlphaFold + ColabFold UniProt A0A0V9RK72
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Amino acids 185
Annotations 3
Features 22
PDB binders 0
Druggability 0.775

Overview

Basic information about this protein and its source genome.

Accession
KP13_03900
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45354.1 puuR
Status
annotated
Amino acids
185
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.775
Structure A0A0V9RK72
Pocket Pocket 1
P2Rank 0.614
Structure A0A0V9RK72
Pocket Pocket 1
ColabFold model
FPocket 0.214 · Pocket 2
P2Rank 0.482 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 55 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
13 66 Pfam PF01381 Helix-turn-helix
13 66 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
92 181 CDD cd02209 cupin_XRE_C
79 184 Gene3D G3DSA:2.60.120.10 Jelly Rolls
79 184 InterPro IPR014710 RmlC-like jelly roll fold
9 183 PANTHER PTHR46797 HTH-TYPE TRANSCRIPTIONAL REGULATOR
7 78 FunFam G3DSA:1.10.260.40:FF:000016 HTH-type transcriptional regulator PuuR
7 78 Gene3D G3DSA:1.10.260.40 -
7 78 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
79 184 FunFam G3DSA:2.60.120.10:FF:000029 HTH-type transcriptional regulator PuuR
11 66 SMART SM00530 mbf_short4
11 66 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
7 73 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
7 73 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
12 66 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
12 66 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
111 178 Pfam PF07883 Cupin domain
111 178 InterPro IPR013096 Cupin 2, conserved barrel
51 183 SUPERFAMILY SSF51182 RmlC-like cupins
51 183 InterPro IPR011051 RmlC-like cupin domain superfamily
9 66 CDD cd00093 HTH_XRE
9 66 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0V9RK72
AlphaFold — — full sequence — Viewing
ColabFold KP13_03900
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.775

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.91 0.533