Protein profile

KP13_03885

Sulfurtransferase tusE

Genome: KpKP13

Gene: AHE45368.1 tusE Structure source: AlphaFold + ColabFold UniProt A0A0H3GR56
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Amino acids 109
Annotations 5
Features 15
PDB binders 1
Druggability 0.752

Overview

Basic information about this protein and its source genome.

Accession
KP13_03885
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45368.1 tusE
Status
annotated
Amino acids
109
Structure source
AlphaFold + ColabFold
EC
2.8.1.-
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.908
DEG E-value
7.93e-71
Localization
Cytoplasmic
ColabFold pLDDT
94.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.752
Structure A0A0H3GR56
Pocket Pocket 1
P2Rank 0.005
Structure A0A0H3GR56
Pocket Pocket 1
ColabFold model
FPocket 0.333 · Pocket 6
P2Rank 0.005 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 149 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
  • GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
2 37 Gene3D G3DSA:3.30.1420.10 -
2 37 InterPro IPR043163 DsrC-like protein, N-terminal domain
3 109 SUPERFAMILY SSF69721 DsrC, the gamma subunit of dissimilatory sulfite reductase
3 109 InterPro IPR025526 DsrC-like domain superfamily
1 38 FunFam G3DSA:3.30.1420.10:FF:000001 Sulfurtransferase
4 109 Pfam PF04358 DsrC like protein
4 109 InterPro IPR007453 Sulphur transfer protein DsrC/TusE
39 109 Gene3D G3DSA:1.10.10.370 -
39 109 InterPro IPR042072 DsrC-like protein, C-terminal domain
4 109 NCBIfam TIGR03342 TusE/DsrC/DsvC family sulfur relay protein
2 109 PIRSF PIRSF006223 DsrC_TusE
2 109 InterPro IPR007453 Sulphur transfer protein DsrC/TusE
3 109 PANTHER PTHR37010 SULFURTRANSFERASE TUSE
3 109 InterPro IPR007453 Sulphur transfer protein DsrC/TusE
39 109 FunFam G3DSA:1.10.10.370:FF:000001 Sulfurtransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR56
AlphaFold — — full sequence — Viewing
ColabFold KP13_03885
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.752

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.9 0.004

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
SH0
2V4J
P45573 868.9 Da LogP 3.40 TPSA 347.2 3 viol. ✓ Clean C[C@@]\1([C@@H](C2/C=C\3/[C@@]([C@@H](/C(=C/C4=…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.